Friday, January 6, 2017 from 9:00am – 11:00am
Charles Epstein, MD Professor in the Neurology Department at Emory University and Mukesh Dhamala, PhD Associate Professor in the Physics Department at Georgia State University, will be speaking on “Application of High and Low Frequency Granger Causality in Localization of Epileptic Seizures”
Despite advances in drug therapy and neuroimaging, many thousands of epilepsy patients in the US have seizures that are refractory to medication and cannot be localized for surgery without intracranial recording. But even when recording EEG from inside the head, seizure origin may be difficult to identify definitively. Seizures may appear nonlocalizing by conventional visual standards, and present criteria for intracranial seizure onset may be inadequate for many patients.
For several years we have collaborated in using Granger causality analysis of high frequency intracranial EEG activity, prior to visible seizure onset, to help identify seizure origin. Intracranial infraslow EEG has also been suggested to have localizing value for seizures. We have more recently begun applying Granger causality to preictal infraslow EEG, and will be discussing and comparing our results with both of these extreme frequency ranges.
John Gale, PhD, Associate Professor in the Neurosurgery Department at Emory University, will be speaking on "Micro-Magnetic Stimulation: Advantages, Limitations, and Future.