The overarching research goals within the Exercise Physiology Laboratory are to seek nutritional and exercise interventions that can improve human health, well-being and performance. Our group has been particularly focused on the importance of hydration to delay fatigue and maintain safety during exercise, especially in conditions of heat stress. The physiological responses and efficacy of specific interventions related to nutrient composition and dosage (e.g. during and following physical activity) have been studied. Health and work performance issues that relate to body fluid balance and provision of optimal macronutrients have implications for a variety of populations during exercise that may be specific to fitness level, age, and gender.