Synaptic Neurotransmitter Spillover, ALS: Initiation and Progression Methodologies
The conceptualization of biological processes and function is the essence of physiological study. Conceptualization is a necessity in biological systems due to their inherent complexity including the emergence of properties, functions and processes, and the concomitant restriction of other properties, functions and processes. However, “conceptualization” is human endeavor and as such can over-, under- and simply mis-conceptualize. We contend, therefore, that bioscientific inquiry is as much about understanding and managing our own conceptualizations as it is understanding the biophysical processes at work. To this end, we have developed several novel approaches to modeling and analysis of biological systems that facilitate assessing our own uncertainty regarding both the biological system and our conceptualizations of it. The primary focus of this lab is the advancement of our understanding of neural-related physiological and pathological systems by application of these techniques.